Figure 1.

Comparison of accumulated amyloid-β in sporadic and familial Alzheimer’s disease in different brain areas. After normalization within each individual, amyloid-β₄₀ (Aβ₄₀) levels (A) and amyloid-β₄₂ (Aβ₄₂) levels (B) in the GuHCl fraction from cases with sporadic or familial Alzheimer’s disease are plotted for 12 brain areas with a box-and-whisker diagram. In this and subsequent figures, blue areas = neocortical areas; purple areas = limbic areas; and orange areas = subcortical areas. *P < 0.05, **P < 0.01, ***P < 0.001; Wilcoxon rank-sum test. AM = amygdala; CB = cerebellum; DF = dorsolateral prefrontal cortex; EC = entorhinal cortex; FA = familial Alzheimer’s disease; HT = hypothalamus; IP = inferior parietal cortex; IT = inferior temporal cortex; OF = orbitofrontal cortex; PC = posterior cingulate cortex; SA = sporadic Alzheimer’s disease; ST = striatum; TL = thalamus; VC = primary visual cortex.