. 2014 Mar 12;137(5):1533–1549. doi: 10.1093/brain/awu046

Table 6.

Regional associations between accumulated amyloid-β in sporadic or familial Alzheimer’s disease and molecules related to amyloid-β metabolism in normal ageing

	Sporadic Alzheimer’s disease				Familial Alzheimer’s disease
	Amyloid-β₄₀ GuHCl		Amyloid-β₄₂ GuHCl		Amyloid-β₄₀ GuHCl		Amyloid-β₄₂ GuHCl
	r	P-value	r	P-value	r	P-value	r	P-value
ApoE TBS	−0.783	0.003	−0.532	0.075	−0.580	0.048	−0.007	0.983
ApoE TX	−0.811	0.001	−0.720	0.008	−0.671	0.017	−0.294	0.354
ApoE GuHCl	−0.713	0.009	−0.657	0.020	−0.518	0.085	−0.140	0.665
APP	0.217	0.499	0.664	0.019	−0.014	0.966	0.832	<0.001
APP-CTFβ	−0.126	0.697	0.406	0.191	−0.322	0.308	0.783	0.003
BACE1	−0.273	0.391	−0.189	0.557	−0.084	0.795	0.098	0.762
PSEN1	0.601	0.039	0.811	0.001	0.112	0.729	0.580	0.048
NEP	−0.245	0.443	0.028	0.931	−0.469	0.125	0.035	0.914
IDE	0.888	<0.001	0.811	0.001	0.511	0.090	0.343	0.276
LRP1	0.622	0.031	0.804	0.002	0.315	0.319	0.692	0.013
LDLR	−0.266	0.404	−0.357	0.255	0.084	0.795	−0.266	0.404
GFAP	−0.951	<0.001	−0.615	0.033	−0.608	0.036	−0.028	0.931
SYP	0.462	0.131	0.601	0.039	0.021	0.948	0.539	0.071
PSD95	0.755	0.005	0.923	<0.001	0.350	0.265	0.706	0.010

Correlation coefficient (r) and P-value were acquired by the non-parametric Spearman rank test comparing median value of normalized levels of amyloid-β in the GuHCl fraction in cases with sporadic or familial Alzheimer’s disease with median value of normalized levels of molecules related to amyloid-β metabolism in normal ageing cases across 12 brain regions. Significant correlations are shown as bold text.