Table 3.
Summary of pre-clinical and clinical studies using mesenchymal stem cell for peripheral nerve injury
| Animal | Nerve | Lesion type | Cells source | Route of administration | Ref. |
| Mouse | Median | Transection | Bone marrow-MSC | Local | [147] |
| Mouse | Ischiatic | Transection | Bone marrow-MSC | Local | [148] |
| Mouse | Ischiatic | Transection | Embryonic stem cell derived-MSC | Local | [144] |
| Mouse | Ischiatic | Crush | Adipose derived-MSC | Intravenous | [149] |
| Mouse | Ischiatic | Transection | Bone marrow-MSC | Local | [131] |
| Rat | Ischiatic | Crush | Amniotic fluid derived-MSC | Local | [150] |
| Rat | Ischiatic | Crush | Amniotic fluid derived-MSC | Intravenous | [151-153] |
| Rat | Facial | Transection | Bone marrow-MSC | Local | [154,155] |
| Rat | Ischiatic | Crush | Bone marrow-MSC | Local | [156] |
| Rat | Ischiatic | Transection | Adipose derived-MSC | Local | [157-159] |
| Rat | Ischiatic | Transection | Umbilical cord derived-MSC | Local | [160,161] |
| Rat | Ischiatic | Transection | Bone marrow-MSC | Local | [145,158,162-169] |
| Rat | Cavernous | Traction | Bone marrow-MSC | Intracavernousal injection | [170] |
| Rabbit | Facial | Transection | Bone marrow-MSC | Local | [171] |
| Rabbit | Ischiatic | Traction | Bone marrow-MSC | Local | [172,173] |
| Pig | Ischiatic | Transection | Bone marrow-MSC | Local | [174] |
| Dog | Ischiatic | Transection | Bone marrow-MSC | Local | [140,175] |
| Dog | Ischiatic | Transection | Adipose derived-MSC | Local | [176] |
| Monkey | Median | Transection | Bone marrow-MSC | Local | [142] |
| Human | Median or ulnar | Transection | Bone marrow mononuclear cell fraction-MSC | Local | [146] |
MSC: Mesenchymal stem cell.