Table 1.
Nuclear receptor | Expressing tissues | Function | Phenotypes of knockout mice |
SF-1/Ad4BP/NR5A1 | Testis, ovary, adrenal, | Steroidogenesis Sex differentiation Energy homeostasis | Adrenal and gonadal agenesis |
Sex reversal in external genitalia | |||
Impaired expression of pituitary gonadotropins | |||
Abnormality of ventromedial hypothalamic nucleus | |||
LRH-1/NR5A2 | Ovary, testis, liver, pancreas, intestine, early embryo | Steroidogenesis Ovulation Bile acid synthesis Glucose metabolism | Embryonic lethal around E6.5-7.5 d |