Table 1.

Summary of the characteristics of steroidogenic factor-1 and liver receptor homolog-1

Nuclear receptor	Expressing tissues	Function	Phenotypes of knockout mice
SF-1/Ad4BP/NR5A1	Testis, ovary, adrenal,	Steroidogenesis Sex differentiation Energy homeostasis	Adrenal and gonadal agenesis
			Sex reversal in external genitalia
			Impaired expression of pituitary gonadotropins
			Abnormality of ventromedial hypothalamic nucleus
LRH-1/NR5A2	Ovary, testis, liver, pancreas, intestine, early embryo	Steroidogenesis Ovulation Bile acid synthesis Glucose metabolism	Embryonic lethal around E6.5-7.5 d