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. Author manuscript; available in PMC: 2014 Apr 25.
Published in final edited form as: Bull Math Biol. 2013 May 18;76(4):766–798. doi: 10.1007/s11538-013-9842-5

Fig. 1.

Fig. 1

The negative feedback loop in the Hes1 GRN. When the promoter site is free, hes1 mRNA is transcribed at its maximal rate. The nascent mRNA then diffuses and is exported to the cytoplasm where it produces Hes1 protein monomers via the process of translation. Hes1 monomers bind together to form dimers in the cytoplasm. Hes1 dimers diffuse and are imported into the nucleus. They go on to occupy the hes1 promoter and repress the transcription of hes1 mRNA. The occupied promoter site is still able to produce hes1 mRNA, but at a significantly reduced rate (Takebayashi et al. 1994) (Color figure online)