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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Immunol Methods. 2013 Jun 13;395(0):1–13. doi: 10.1016/j.jim.2013.06.001

Figure 10. Pooled ROC Variability.

Figure 10

ROCs based on the “Pooled” baseline correction method, using Z-scale normalized peptide intensities in RV144a. Each black line is an ROC generated by randomly sampling n pre-treatment subjects for use as an averaged baseline. The blue line is a smoother applied to the set of black ROCs, giving an “average” ROC for a given sample size. This gives an idea of the variability associated with using a sample size of n as a pooled baseline control. ROC variability decreases quickly as sample sizes increase.