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. 2014 Mar 19;13:61. doi: 10.1186/1476-4598-13-61

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Copyright © 2014 Selvaraj et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Prostate cell lines vary in oncogenic ETS expression and RAS/ERK pathway activation. (A) The sensitivity and specificity of antibodies detecting oncogenic ETS proteins were tested by immunoblot of the indicated amount of purified full-length proteins. (B) Immunoblots show levels of four oncogenic ETS proteins, pAKT (PI3K/AKT activation), pERK (RAS/ERK activation), total ERK, and tubulin control in six prostate cancer cell lines (left) and three cell lines derived from normal prostate (right). (C) Immunoblots show levels of ETV4 and pERK in the indicated cell lines with or without U0126 (10 μM, 10 hr). The same cell extracts are loaded on one gel above the dashed line, and a second gel below. ETV4 is only visible in DU145 cells after a very long exposure, hence it is not observed in (A).