Table I.
Baseline characteristics.
| AZA | LDara-C | |
|---|---|---|
| Parameter | N = 45 | N = 49 |
| Median age, years (range) | 69·0 (42–82) | 71·0 (56–85) |
| Age categories, n (%) | ||
| <65 years | 14 (31) | 7 (14) |
| 65–74 years | 21 (47) | 28 (57) |
| ≥75 years | 10 (22) | 14 (29) |
| Male gender – n (%) | 39 (87) | 35 (71) |
| FAB Classification – n (%) | ||
| RAEB | 27 (60) | 25 (51) |
| RAEB-t | 15 (33) | 19 (39) |
| CMML | 1 (2·2) | 1 (2·0) |
| AML | 1 (2·2) | 0 |
| MPD | 0 | 1 (2·0) |
| Indeterminate | 1 (2·2) | 3 (6·1) |
| IPSS – n (%) | ||
| Intermediate-1 | 1 (2·2) | 2 (4·1) |
| Intermediate-2 | 22 (49) | 21 (43) |
| High | 19 (42) | 21 (43) |
| Indeterminate | 2 (4·4) | 4 (8·2) |
| Not applicable★ | 1 (2·2) | 1 (2·0) |
| ECOG Status – n (%) | ||
| Grade 0 | 21 (47) | 29 (59) |
| Grade 1 | 21 (47) | 17 (35) |
| Grade 2 | 1 (2) | 2 (4) |
| Missing | 2 (4) | 1 (2) |
| # RBC transfusions – median (range) during the 56 d prior to study enrollment | 2·0 (0–9) | 1·0 (0–10) |
| Hb (g/l) – median (range) | 96 (71–122) | 97 (54–143) |
| Platelet count (109/l) – median (range) | 42 (7–252) | 84 (18–437) |
| ANC (109/l) – median (range) | 0·8 (0–7·9) | 1·3 (0·2–18·7) |
FAB, French-American- British; RAEB, refractory anaemia with excess blasts; RAEB-t, RAEB in transformation; CMML, chronic myelo-monocytic leukaemia; AML, acute myeoid leukaemia; MPD, myelo-proliferative disease; IPSS, International Prognostic Scoring System; ECOG, Eastern Cooperative Oncology Group; RBC, red blood cell; Hb, haemoglobin; ANC, absolute neutrophil count.
★
IPSS classification was not applicable for patients who were classified as AML or MPD (per the FAB classification) because the IPSS classification was not developed for those patients.