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. Author manuscript; available in PMC: 2015 Mar 1.

Published in final edited form as: JAMA Neurol. 2014 Mar;71(3):306–314. doi: 10.1001/jamaneurol.2013.5993

MRI evidence of MS activity (panels A and B) and progression (panel C). A: Rate ratio of new active lesions on brain MRI up to year 5. B: Change of T2 lesion volume on brain MRI from year 1 to year 5 by quintiles of serum 25(OH)D. C: Annualized change in EDSS from 6 months to year 5 by quintiles of serum 25(OH)D.

MRI evidence of MS activity (panels A and B) and progression (panel C). A: Rate ratio of new active lesions on brain MRI up to year 5. B: Change of T2 lesion volume on brain MRI from year 1 to year 5 by quintiles of serum 25(OH)D. C: Annualized change in EDSS from 6 months to year 5 by quintiles of serum 25(OH)D.