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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: JAMA Neurol. 2014 Mar;71(3):306–314. doi: 10.1001/jamaneurol.2013.5993

Table 2.

Rate ratios (RR) for new active lesions on brain MRI and MS relapses according to a 50 nmol/L increment in serum 25(OH)D levels.

Period All patients (N=454) No missing 6 or 12M 25(OH)D (N=334)
Baseline to 60M Baseline to 60M 12M to 60M 24M to 60M
25(OH)D Cumulative average - Updated to 24M Cumulative average - Updated to 24M Cumulative average – updated to 12M Cumulative average – updated to 12M
RR (95% CI) p RR (95% CI) p RR (95% CI) p RR (95% CI) p
New active lesions 0·61 (0·44–0·83) 0·002 0·54 (0·37–0·78) 0·001 0·43 (0·26–0·70) 0·0009 0·37 (0·21–0·63) 0·0004
 Relapses 0·73 (0·46–1·16) 0·19 0·66 (0·38–1·17) 0·16 0·43 (0·20–0·92) 0·03 0·41 (0·16–1·06) 0·06

RR adjusted for age, sex, treatment, time of follow-up, T2 lesion score at baseline, and type of onset.