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. 2014 Mar 20;14:213. doi: 10.1186/1471-2407-14-213

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Copyright © 2014 Martínez et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DNA methylation alterations on grade II and malignant PXA samples. Based on methylation frequencies, tumor samples can be categorized on three groups: (1) grade II PXA (PXA 1-3); (2) precursor and anaplastic PXA (PXA 4-5) and (3) GBM. PXA-4 and PXA-5 samples show increased DNA methylation when compared with grade II PXA. A set of genes was observed to be commonly hypermethylated in anaplastic PXA, its grade II PXA precursor and GBM, whereas being unmethylated in all other grade II PXA and normal brain (squared in blue). Color scale shows methylated (red) and unmethylated (green) status of the probes.