Figure 5.

Comparison of the distributions of the scaled rankings of the gene sets for the various methods for the TF (a-d) and drug (e-f) perturbations. Each sub-plot shows the deviation of the cumulative distribution from uniform of the rankings of each gene set and analysis method, (a) the TF perturbed by each experiment; b) genes associated with binding sites of the TF as measured in ChIP-Seq experiments from ChEA; c) the genes interacting with the TF or the gene that encodes the TF; d) genes associated with binding sites of the TF as measured in ChIP-Seq experiments from ENCODE; The perturbation of the cumulative distribution of the rankings of (e) drug targets, and (f) genes that their protein product are known to interact with the drug targets.