Table 4.
Lymphocyte subsets | Healthy controls (n = 30) | Phase | Silent infection (n = 30) | Minor infection (n = 27) | Severe infection (n = 34) | P -value |
---|---|---|---|---|---|---|
mDC/PBMC, % |
0.53 ± 0.13 |
AP |
1.09 ± 0.34b |
0.81 ± 0.48b,c |
0.53 ± 0.24c,d |
<0.0001a |
CP |
0.89 ± 0.43b,e |
ND |
0.70 ± 0.30e |
0.0014a |
||
pDC/PBMC, % |
0.24 ± 0.11 |
AP |
0.42 ± 0.21b |
0.39 ± 0.23b |
0.22 ± 0.14c,d |
<0.0001a |
CP |
0.37 ± 0.22b |
ND |
0.38 ± 0.12b,e |
0.0048a |
||
IFN-γ
+
CD4/CD3, % |
23.09 ± 6.03 |
AP |
17.41 ± 7.75b |
16.13 ± 5.60b,d |
23.94 ± 6.72c,d |
<0.0001a |
CP |
23.38 ± 6.81e |
ND |
24.50 ± 8.73 |
0.0001a |
||
IFN-γ + CD8/CD3, % |
14.30 ± 5.65 |
AP |
15.88 ± 8.17 |
12.53 ± 6.33 |
18.30 ± 8.23 |
0.0251 |
CP |
23.30 ± 8.94b,e |
ND |
18.40 ± 8.66d |
0.0003a |
||
IL-17
+
CD4/CD3, % |
2.06 ± 0.94 |
AP |
1.74 ± 0.96 |
1.93 ± 0.89d |
2.84 ± 1.19b,c,d |
0.0004a |
CP |
3.37 ± 1.47b,e |
ND |
3.04 ± 1.36b |
0.0002a |
||
IL-17
+
CD8/CD3, % |
0.22 ± 0.17 |
AP |
0.54 ± 0.33b |
0.40 ± 0.22b,d |
0.25 ± 0.18c |
<0.0001a |
CP | 0.81 ± 0.34b | ND | 0.74 ± 0.69b | <0.0001a |
DC, dendritic cell; AP, acute phase; PBMC, peripheral blood mononuclear cell; CP, convalescent phase; ND, not determined.
asignificant differences in the four groups by one-way ANOVA.
bsignificant difference from the healthy control group.
csignificant difference from the silent infection group.
dsignificant difference from the minor infection group.
esignificant difference from the AP within a group.