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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: Cell. 2014 Mar 13;156(6):1193–1206. doi: 10.1016/j.cell.2014.02.008

Figure 3. Cryo-EM Structure of the ASCPYD Filament at Near Atomic Resolution.

Figure 3

A. A cryo-EM image of ASCPYD filaments.

B. Average power spectra of ASCPYD filaments in two twist bins (left and right halves) showing constant axial rise per subunit (blue arrow) and variable long-range twist features (red arrows).

C. Filament segments can be divided into separate twist bins according to azimuth angle, or rotation per subunit.

D. Cryo-EM reconstruction of the ASCPYD filament, superimposed with the final atomic model shown in three colors each for one start of the three-start helical assembly.

E. A zoom up view of helix α6 shown in stick model and superimposed with the EM density.

See also Figure S3 and Movie S1.