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. 2014 Apr 30;27(1):31–42. doi: 10.1293/tox.2013-0033

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©2014 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 3. — Treatment with AZD3783 for 3 months at 15 or 30 mg/kg/day caused degenerative and inflammatory lesions in the central and peripheral nervous tissues. (A) Ganglion cell vacuolation and mononuclear cell infiltration in the DRG; (B) Necrosis and inflammation in the cochlear nuclei; (C) Neuronal degeneration/necrosis and inflammation in the CA2 region of the hippocampus; (D) Perivascular mononuclear cell infiltration in the retina. H&E staining, 200×. In the insert, the arrow points to eosinophilic inclusion body.