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Compound-induced lesions in the brain of dogs treated with AZD3783 are irreversible. (A) Hippocampus CA4 region of vehicle-treated control dog; (B) Extensive neuronal loss and prominent astrogliosis in the hippocampus CA4 region of a dog treated with AZD3783 at 30 mg/kg/day for 3 months and then being dose-free for 5 weeks. H&E staining, 200×.
