Table 2. Association of pAMPK expression with clinicopathological features and pACC and pERK expression.
Negative pAMPK | Positive pAMPK | P value | |
n = 42 (%) | n = 76 (%) | ||
Age, median (range) | |||
<60 years | 23 (54.8) | 57 (75.0) | 0.024*C |
≥60 years | 19 (45.2) | 19 (25.0) | |
Gender | |||
Female | 3 (7.1) | 6 (7.9) | 1.000F |
Male | 39 (92.9) | 70 (92.1) | |
(Neo)Adjuvant | |||
None | 20 (47.6) | 37 (48.7) | 0.912C |
Any | 22 (52.4) | 39 (51.3) | |
T | |||
T1/T2 | 24 (57.1) | 59 (77.6) | 0.020*C |
T3/T4 | 18 (42.9) | 17 (22.4) | |
N | |||
N0 | 31 (73.8) | 50 (65.8) | 0.369C |
N1/N2 | 11 (26.2) | 26 (34.2) | |
Stage | |||
I/II | 21 (50.0) | 42 (55.3) | 0.583C |
III/IV | 21 (50.0) | 34 (44.7) | |
Site | |||
Non-oral cavity | 8 (19.0) | 4 (5.3) | 0.026*F |
Oral cavity | 34 (81.0) | 72 (94.7) | |
Differentiation | |||
Well to moderate | 34 (81.0) | 53 (69.7) | 0.200F |
Poorly | 8 (19.0) | 23 (30.3) | |
Margin | |||
Negative | 27 (67.5) | 58 (77.3) | 0.253C |
Positive | 13 (32.5) | 17 (22.7) | |
Lymphovascular invasion | |||
Negative | 25 (78.1) | 51 (83.6) | 0.577F |
Positive | 7 (21.9) | 10 (16.4) | |
pACC | |||
Negative or low expression | 33 (78.6) | 62 (81.6) | 0.809F |
High expression | 9 (21.4) | 14 (18.4) | |
pErk | |||
Negative | 33 (78.6) | 50 (65.8) | 0.206F |
Positive | 9 (21.4) | 26 (34.2) |
χ2 test; FFisher’s exact test; *P<0.05.
T, tumor; N, node; pACC, phosphorylated acetyl-CoA carboxylase; pErK, phosphorylated extracellular signal-regulated kinase; pAMPK, phosphorylated AMP-activated protein kinase; n, patient number.