Table 4. Multivariate analysis of overall survival according to nodal status.

	Node negative (n = 81)		Node positive (n = 37)
Variables	Adjusted HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Age
≥60 vs. <60 years	2.26 (0.89–5.70)	0.085**	5.25 (1.68–16.36)	0.004*
Gender
Male vs. Female	0.21 (0.05–0.81)	0.024*	0.74 (0.15–3.65)	0.713
Site
Oral cavity vs. Non-oral cavity	0.93 (0.29–2.96)	0.898	2.39 (0.40–14.28)	0.339
T
T3/T4 vs. T1/T2	3.70 (1.43–9.58)	0.007*	2.17 (0.69–6.86)	0.186
(Neo)Adjuvant treatment
Any vs. None	1.14 (0.46–2.86)	0.774	1.54 (0.27–8.74)	0.625
pAMPK
Positive vs. negative	0.45 (0.19–1.08)	0.072**	0.67 (0.23–1.97 )	0.472
pACC
High expression vs. negative or low expression	1.55 (0.61–3.88)	0.355	17.58 (3.50–88.18)	<0.001*
pErk
Positive vs. negative	0.49 (0.15–1.58)	0.232	0.41 (0.11–1.53)	0.184

*P<0.05; **P<0.1.

T, tumor; pAMPK, phosphorylated AMP-activated protein kinase; pACC, phosphorylated acetyl-CoA carboxylase; pErK, phosphorylated extracellular signal-regulated kinase; n, patient number; HR, hazard ratio; 95% CI, 95% confidence interval.