Table 2.
Etiopathogenic disorders associated with neuropathic pain syndromes*
Toxicity | Chemotherapy, radiotherapy, arsenic/lead exposure, statin and isoniazid usage |
Trauma | Phantom limb pain, postmastectomy pain, postthoracotomy pain, or any pain in major surgical regions |
Compression | Nerve-entrapment syndromes like carpel tunnel syndrome, direct tumor compression, especially in tumor metastasis |
Ischemia | Pain in diabetic food ulcers, vasculitis-associated neuropathy, Buerger’s disease |
Infection | Postherpetic neuralgia, human immunodeficiency virus-associated neuropathy, herpes zoster-associated leprosy |
Congenital diseases | Storage diseases, Fabry’s disease, amyloidosis |
Autoimmune disorders | Chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, vasculitic neuropathy, and paraneoplastic syndromes like Eaton–Lambert syndrome, multiple sclerosis |
Metabolic disorders | Diabetic neuropathy, uremic neuropathy, alcohol toxicity, beriberi |
Note:
Some of these mechanisms usually coexist in neuropathic pain syndromes.