Table 2.
Comparison of Children With and Without Vertebral Deformity According to the Genant Semi-Quantitative Method
| Clinical Characteristics | Children Without Vertebral Deformity n = 72 |
Children With Vertebral Deformity n = 6 |
p |
|---|---|---|---|
| Demographic Data | |||
| Chronological age, median (min, max) in years | 4.4 (1.3, 16.9) | 6.0 (3.2, 9.2) | 0.574 |
| Male, n (%) | 44 (61) | 1 (17) | 0.078 |
| Diagnosis, n (%) | |||
| Minimal Change NS | 53 (74) | 5 (83) | 1.000 |
| Glucocorticoid Treatment* | |||
| Cumulative GC dose (mg/m2) between GC initiation and LS BMD, median (min, max) | 943 (0, 3909) | 1737 (288, 2052) | 0.129 |
| GC dose intensity (mg/m2/day) between GC initiation and LS BMD, median (min, max) | 57 (0, 458) | 59 (41, 71) | 0.680 |
| Average GC dose (mg/m2/day) between GC initiation and LS BMD, median (min, max) | 55 (0, 458) | 58 (41, 70) | 0.793 |
| Total Vitamin D (n=76) and Calcium Intake (n=75) | |||
| Total vitamin D daily intake (% of DRI), n (%) of patients in each category | |||
| < 50 % | 15 (21) | 4 (67) | |
| 50 – <100 % | 17 (24) | 2 (33) | 0.012 |
| >= 100% | 38 (54) | 0 (0) | |
| Vitamin D Supplementation – Yes, n (%) | 25 (35) | 0 (0) | 0.169 |
| Total calcium daily intake (% of DRI), n (%) of patients in each category | |||
| < 50 % | 1 (2) | 0 (0) | |
| 50 – <100 % | 3 (4) | 2 (33) | 0.070 |
| >= 100% | 65 (94) | 4 (67) | |
| Calcium Supplementation – Yes, n (%) | 17 (24) | 1 (17) | 1.000 |
| Lumbar Spine (LS) BMD | |||
| LS BMD Z-score, mean (SD) | −0.52 (1.1) | −0.58 (1.4) | 0.851 |
SD=Standard deviation, LS BMD= Lumbar Spine Bone Mineral density, GC=Glucocorticoids
*
GC dose is reported in prednisone equivalents