Table 3.

LS BMD Z-Score Multiple Linear Regression Analysis

	Model 1		Model 2		Model 3
	Cumulative GC Dose*		GC Dose Intensity#		Average GC Dose&
Clinical Parameters	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
Height Z-Score	0.161 (−0.154, 0.476)	0.311	0.240 (−0.076, 0.555)	0.134	0.208 (−0.103, 0.519)	0.186
Weight Z-Score	0.323 (0.038, 0.607)	0.027	0.266 (−0.021, 0.554)	0.069	0.283 (−0.002, 0.567)	0.052
Age	0.022 (−0.039, 0.083)	0.472	0.015 (−0.047, 0.076)	0.634	0.018 (−0.042, 0.079)	0.548
Gender (female vs. male)	0.449 (−0.016, 0.914)	0.058	0.458 (−0.001, 0.918)	0.051	0.434 (−0.023, 0.890)	0.062
Physical Activity 1	0.360 (−0.131, 0.851)	0.148	0.363 (−0.126, 0.851)	0.143	0.386 (−0.102, 0.874)	0.119
Vitamin D Supplementation	−0.058 (−0.747, 0.632)	0.867	−0.064 (−0.752, 0.624)	0.853	−0.091 (−0.778, 0.595)	0.791
Calcium Supplementation	0.188 (−0.559, 0.935)	0.616	0.188 (−0.546, 0.922)	0.610	0.235 (−0.491, 0.962)	0.519
MCD vs. Other Diagnosis	0.065 (−0.479, 0.610)	0.812	0.049 (−0.489, 0.588)	0.856	0.037 (−0.501, 0.575)	0.891
GC Exposure	−0.367 (−0.692, −0.041)	0.028	−0.017 (−0.029, −0.005)	0.007	−0.016 (−0.028, −0.005)	0.006
Model R2	0.303		0.332		0.336

Note: One patient identified as having an extreme outlier value for GC dose Intensity (458 mg/m2/day) and Average GC dose (458 mg/m2/day) was excluded from Models 2 and 3, as described in the results.

¹As measured by The Habitual Activity Estimation Scale. Highest Tertile of Very Active Weekend Hours versus Tertiles 1 and 2.

^*Total amount of GC received during the observation period relative to body surface area (g/m²)

^# Ratio between the total amount of GC received during the observation period and the number of days when GC treatment was received. This ratio was expressed relative to body surface area

^& Ratio between the total amount of GC received during the observation period and the number of days since the first GC was taken. This ratio was expressed relative to body surface area