Table 1.

Values of the parameters of the genetic heterogeneity models used in the simulation study.

DS variant	mode of inheritance	risk allele frequency	relative Dd	risk DD
Model 2G3Ca (φb = 0.009, Kc = 0.015)
1	Dominant	0.029	7.4	7.4
2	Recessive	0.239	1	7.4
Model 4G5C (φ = 0.008, K = 0.01)
1	Dominant	0.011	4	4
2	Recessive	0.147	1	4
3	Additive	0.032	2	4
4	Additive	0.032	2	4

^aSee text for definition of the model labels.

^bRisk of disease in subjects with low risk genotypes at all loci.

^cPopulation prevalence of the disease.