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. 2014 May;146(5):1325–1338. doi: 10.1053/j.gastro.2014.01.053

Figure 1.

Figure 1

Flvcr1a deletion in the liver alters hepatic heme/iron homeostasis. Data on the livers of 2- (A–D) and 6-month-old (A–F) Flvcr1afl/fl and Flvcr1afl/fl;alb-cre mice are shown. Heme (A) and iron (B) content. (A) n = 10. (B) n = 10. Liver sections of 6-month-old mice stained with Perl's reaction are shown on the right. Scale bar = 300 μm. (C) HO activity and bile bilirubin content, n = 5. (D) malondialdehyde (MDA) content, n = 14. (E) Quantitative real-time polymerase chain reaction (qRT-PCR) analysis of Flvcr1a, Ho-1, Fpn, H- and L-ferritin (Ft) mRNA level (n = 6) and representative Western blots of HO-1, L- and H-Ft and FPN protein, n = 10. (F) qRT-PCR analysis of Txnrd1, γ-gcs, and Sod1 mRNA level (n = 5). Unpaired T test analysis with Welch's correction was performed. AU, arbitrary units; RQ, relative quantity. *P < .05; **P < .01; ***P < .001.