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. 2014 May;146(5):1325–1338. doi: 10.1053/j.gastro.2014.01.053

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© 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

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The increase of cytosolic heme pool size due to Flvcr1a deficiency inhibits ALAS1 and induces HO-1, impairing CYP activity. Data on the liver of Flvcr1a^fl/fl and Flvcr1a^fl/fl;alb-cre mice after dexamethasone or B(a)P treatment are shown on the left and right, respectively. (A) ALAS1 expression and ALAS activity (n = 8). (B) HO-1 expression and HO activity (n = 8). (C) Cytosolic and microsomal heme content (n = 5). (D) Quantitative real-time polymerase chain reaction analysis of Cyp3a11/Cyp1a1 mRNA level and representative Western blot of CYP3A/CYP1A1 protein. (E) CYP3A and CYP1A1 activity (n = 7). Two-way analysis of variance with Bonferroni post-test analysis was performed. *P < .05; **P < .01; ***P < .001; ****P < .0001.