Skip to main content
. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Behav Brain Res. 2014 Feb 28;265:171–180. doi: 10.1016/j.bbr.2014.02.033

Figure 3.

Figure 3

BMMNCs improve learning and memory at day 28 after treatment. (A) Latency to find the platform in the Morris Water Maze test. Rats that had undergone 2VO exhibited worse performance than did the sham-operated rats. Treatment of 2VO rats with BMMNCs decreased the latency to find the platform (improved learning) compared to vehicle treatment. 2VO rats infused with SU5416 (2VO+SU5416) had poorer performance than did the 2VO+vehicle and 2VO+ SU5416+BMMNC groups. *p<0.01 vs. the sham groups; #p<0.01 vs. the other three 2VO groups; †p<0.05 vs. 2VO+vehicle group. (B) There was no difference in swimming speed among the six groups during the five sessions. (C) Quantification of time spent in the target zone during the probe trial indicated that sham groups spent more time in the correct quadrant than did the 2VO groups. The 2VO+BMMNC group exhibited better performance than did the other three 2VO groups. The 2VO+SU5416 group spent less time in the target zone than did the 2VO+SU5416+BMMNC group. *p<0.01 vs. sham groups; #p<0.05 vs. the other three 2VO groups; †p<0.05 vs. 2VO+SU5416+BMMNC group. (D) Sham groups had more crossings of the annulus than did the 2VO groups. 2VO rats treated with BMMNCs had more crossings than did vehicle-treated, SU5416+BMMNC-treated, or SU5416-treated 2VO rats. *p<0.05 vs. sham groups; #p<0.05 vs. the other three 2VO groups. n=12/group.