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Human epidermal growth factor receptor 2 testing algorithm with fluorescence in situ hybridization reflex testing for both immunohistochemistry 2+ and immunohistochemistry 3+. This testing algorithm was recommended by the United States Food and Drug Administration in relation to approval of trastuzumab for advanced gastric cancer. FISH: Fluorescence in situ hybridization; IHC: Immunohistochemistry.
