Figure 5. In Ang-II-induced renal remodeling, elastin degradation and wall-to-lumen ratio is increased in TIMP2-/- mice.
Kidney sections were stained with Van Gieson’s stain and dark grey/black color depicts elastin (a-d). Bar diagram (e) represents the total elastin area against the background presented as mean percent change ± SEM (n=6/group) using WT + Saline as control. Ang-II, angiotensin; TIMP, tissue inhibitor of metalloproteinase; WT, wild-type. *p < 0.05 vs. WT + Ang-II; †p < 0.05 vs. WT + saline; and †p < 0.009 vs. TIMP2-/- + saline. Bar diagram (f) represents the wall- to-lumen ratio of interlobular arteries in the cortex, *p < 0.05 vs. WT + Ang-II; †p = 0.004 vs. WT + saline, †p = 0.01 vs.TIMP2-/- + saline. Original image, × 20 magnification.