Table 4. Comparison of toxicities among studies of q3-week and q2-week TC.
| Completed | Grade ≥2 Rash | Grade ≥2 Neuropathy | Febrile Neutropenia | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Study | Na | n | % | n | % | n | % | cycle 1 GCSF | n | % |
| q3 week TC | ||||||||||
| Jones et al.13 | 506 | 469 | 92.7% | NRb | NR | NR | NR | NR | 25 | 4.9% |
| Takabatake et al.16 | 53 | 50 | 94.3% | 11 | 20.8% | 2 | 3.8% | no | 15 | 28.3% |
| Soong et al.25 | 12 | NR | NR | NR | NR | NR | NR | no | 6 | 50.0% |
| Chan et al.24 | 159 | 140 | 88.1% | NR | NR | NR | NR | no yes |
8/32 8/127 |
25% 6% |
| q2 week TC | ||||||||||
| This study | 41 | 37 | 90.2% | 11 | 26.8% | 6 | 14.6% | yes | 1 | 2.4% |
a
N a total sample size
b
NR, not reported