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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Nat Neurosci. 2014 Mar 30;17(5):664–666. doi: 10.1038/nn.3688

Figure 2. Lumbar spinal cord tissue immunostained for MATR3 and counterstained with hemotoxylin.

Figure 2

(a) Control spinal cord exhibits MATR3 nuclear immunoreactivity in some motor neurons, with weak glial cell immunostaining. (b) ALS cases exhibit strong nuclear immunoreactivity with cytoplasmic immunoreactivity present in some motor neurons either diffusely or in cytoplasmic puncta. Strong glial immunostaining is also noted in ALS patients. (c) Patient with the p.Phe115Cys MATR3 mutation exhibits strong nuclear staining, as well as cytoplasmic staining in many cells. Images are taken at 20× magnification and insets are at 40× magnification. Scale bars represent 50um.