Table 3.
Normalized index of methylation (NIM)% and corresponding p-values
| RASSF1A | APC | MGMT | CDKN2A | CDKN2B | |
|---|---|---|---|---|---|
| Invasive high grade urothelial bladder cancer (n = 33) | |||||
| Mean | 40 | 6.1 | 9 | 0.09 | 0.58 |
| Range | 0-270 | 0-50 | 0-96 | 0-2 | 0-6 |
| Non-invasive low grade urothelial bladder cancer (n = 43) | |||||
| Mean | 2 | 2 | 2.3 | 0.4 | 0.1 |
| Range | 0-49 | 0-43 | 0-41 | 0-8 | 0-2 |
| Normal bladder (n = 10) | |||||
| Mean | 2 | 0 | 0 | 1 | 2 |
| Range | 0-12 | 0 | 0-4 | 0-16 | 0-1 |
| *p-value | <0.001 | <0.001 | <0.001 | 0.748 | 0.114 |
| Plasma samples (n = 16) | |||||
| Mean | 24.9 | 0.035 | 16.2 | 1.5 | 5.9 |
| Range | 3-125 | 0-4.4 | 0.1-111.7 | 0-16.3 | 0.1-18.9 |
| **p-value | 0.539 | <0.001 | 0.524 | 0.215 | <0.01 |
*Kruskal Wallis Test **Paired T-Test (p-value<0.01).