Table 10.
Comparison of Cumulative Incidence of LOAD in First-Degree Relatives in Family-Based Studies
| Study by Participants | No. of Cases | No. of Controls | Cumulative Incidence (95% CI) |
|---|---|---|---|
| Relatives of NIA-LOAD/NCRAD probands | 101 | 448 | 0.18 (0.15–0.22)a |
| Relatives of EFIGA probands | 119 | 331 | 0.26 (0.22–0.30) |
| Steffens et al24 | |||
| First-degree relatives of concordant twins | 16 | 60 | 0.21 (0.12–0.30) |
| First-degree relatives of discordant twins | 38 | 362 | 0.10 (0.06–0.12) |
| Green et al25 | |||
| First-degree relatives, white | 1323 | 16 316 | 0.08 (0.07–0.80) |
| First-degree relatives, African American | 220 | 2061 | 0.10 (0.08–0.11) |
Abbreviations: EFIGA, Estudio Familiar de Influencia Genetica en Alzheimer; LOAD, late-onset Alzheimer disease; NIA-LOAD/NCRAD, National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease.
a
The 95% confidence interval was calculated using a normal approximation method of the binomial confidence interval.