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. Author manuscript; available in PMC: 2014 Apr 27.
Published in final edited form as: JAMA Neurol. 2014 Mar;71(3):315–323. doi: 10.1001/jamaneurol.2013.5570

Table 3.

Incidence Rate of LOAD in NIA-LOAD/NCRAD Families

Age Group, y No. of Cases Person-years at Risk Incidence Rate (95% CI)
65–74 31 1200 0.03 (0.02–0.04)
75–84 46a 820 0.06 (0.04–0.08)
≥85 23 324b 0.07 (0.05–0.11)

Abbreviation: NIA-LOAD/NCRAD, National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease.

a

One individual with incident Alzheimer disease (AD) had positive test results for the R5H mutation in MAPT and was excluded from the incident rate calculation.

b

Includes individuals who were diagnosed as having dementia in the first examination (prevalent dementia) but who did not experience conversion to AD after multiple examinations. These individuals contribute person-years to AD incidence rate calculations but were excluded from dementia subgroup.