Table 8.
APOE-Stratified Incidence Rate of AD
| Age Group, y | No APOE e4 Allele
|
1 or 2 Copies of APOE e4 Allele
|
||||
|---|---|---|---|---|---|---|
| No. of Cases | Person-years at Risk | Incidence Rate (95% CI) | No. of Cases | Person-years at Risk | Incidence Rate (95% CI) | |
| NIA-LOAD/NCRAD Families | ||||||
|
| ||||||
| 65–74 | 10 | 558 | 0.02 (0.01–0.03) | 21 | 543 | 0.04 (0.002–0.06) |
|
| ||||||
| 75–84 | 13 | 409 | 0.03 (0.02–0.05) | 30 | 340 | 0.09 (0.06–0.13) |
|
| ||||||
| ≥85 | 10 | 221 | 0.05 (0.02–0.08) | 9 | 81 | 0.11 (0.05–0.21) |
|
| ||||||
| EFIGA Families | ||||||
|
| ||||||
| 55–64 | 9 | 551 | 0.02 (0.01–0.03) | 10 | 347 | 0.03 (0.01–0.05) |
|
| ||||||
| 65–74 | 25 | 600 | 0.04 (0.03–0.06) | 31 | 55 | 0.06 (0.04–0.08) |
|
| ||||||
| 75–84 | 28 | 396 | 0.07 (0.05–0.10) | 26 | 309 | 0.08 (0.06–0.12) |
|
| ||||||
| ≥85 | 10 | 152 | 0.07 (0.03–0.12) | 6 | 72 | 0.08 (0.02–0.16) |
Abbreviations: AD, Alzheimer disease; APOE, apolipoprotein E; EFIGA, Estudio Familiar de Influencia Genetica en Alzheimer; NIA-LOAD/NCRAD, National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease.