Table 3.
Antihypertensive effect produced by losartan (10 mg/kg) and fractions (50 mg/kg) obtained from SeRAce, on pretreated mice with AG II (1.0 μg/kg, i.v. ).
| Treatment | Systolic BP mmHg | Diastolic BP mmHg |
|---|---|---|
| Vehicle | 127.51 ± 3.24 | 61.14 ± 6.74 |
| AG II | 146.40 ± 3.01 | 95.90 ± 8.01 |
| R2 | 133.98 ± 15.86 | 86.3 ± 14.86 |
| R5 | 122.61 ± 16.43 | 84.5 ± 18.08 |
| R6 | 132.38 ± 17.87 | 93.03 ± 20.83 |
| R8 | 138.01 ± 14.84 | 93.63 ± 13.98 |
| R11 | 119.45 ± 19.85 | 82.07 ± 16.23 |
| R14 | 109.21 ± 13.94* | 68.88 ± 12.10* |
| R17 | 109.09 ± 8.73* | 71.66 ± 14.53* |
| R20 | 122.55 ± 13.15 | 77.71 ± 10.97 |
| Losartan | 119.50 ± 11.73 | 77.45 ± 12.41 |
Data are presented as means ± SD with n = 7. ANOVA and post hoc Bonferroni test. *P < 0.05 is with respect to the negative control (AG II 1.0 μg/kg).