Table 1.
Statistical analysis of genotype distribution of cytochrome P450 (CYP) isoenzymes in EHS-patients self-reporting electromagnetic hypersensitivity (n = 29) versus MCS-multiple chemical sensitivity patients without EHS (n = 85) and of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) isoenzymes in CTR-healthy control subjects (n = 68) versus EHS-patients (n = 127).
| Genotype | CTR | EHS | MCS | P | Odds Ratio | C.I. 95% |
|---|---|---|---|---|---|---|
| CYP2C19 (*1/*1) | 26 (89.7%) | 51 (60.0%) | 0.003 | |||
| CYP2C19 (*1/*2, *2/*2) | 3 (6.9%) | 34 (38.8%) | ||||
| GSTP1 (*A/*A, *A/*B) | 62 (91%) | 104 (82%) |
0.09 n.s. |
|||
| GSTP1 (*B/*B, *B/*C, *C/*C, *A/*C) | 6 (9%) | 23 (18%) | ||||
| GSTM1 (*1/*1, *1/*0) | 36 (53%) | 64 (50%) | n.s. | |||
| GSTM1 (*0/*0) | 32 (47%) | 63 (50%) | ||||
| GSTT1 (*1/*1, *1/*0) | 58 (85%) | 101 (80%) | n.s. | |||
| GSTT1 (*0/*0) | 10 (15%) | 26 (20%) | ||||
| GSTM1 (*1/*1, *1/*0) + GSTT1 (*1/*1, *1/*0) | 67 (98.5%) | 111 (87%) | 0.007 | 9.7 | (1.3–74.5) | |
| GSTM1 (*0/*0) + GSTT1 (*0/*0) | 1 (1.5%) | 16 (13%) |