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The effects of the number of days of chronic nicotine administration on [3H]epibatidine binding in the dorsal hippocampus. Chronic nicotine significantly increased [3H]epibatidine binding in the dorsal hippocampus only after 4 days of administration. Error bars represent ± S.E.M. (*) indicates p < 0.05 compared to saline treated mice (n=9 saline; n= 6 each nicotine group).
