Table 3.
Percent agreement and standard Kappa coefficients for MES versus SEER using FIGO three-tier grading schemes for: 3A) all 664 ovarian tumors and 3B) restricted to tumors with assigned grade (low, intermediate, or high) and also classified as invasive by the study pathologist
| 3A: FIGO, all SEER tumors | 3B: FIGO, restricted | |||||
|---|---|---|---|---|---|---|
| low/intermediate/high | low/intermediate/high | |||||
| n | p0 | κ (95% CI) | n | p0 | κ (95% CI) | |
| Overall | 664 | 0.49 | 0.25 (0.20, 0.30) | 477 | 0.62 | 0.32 (0.26, 0.39) |
| Registry | ||||||
| Hawaii | 516 | 0.49 | 0.24 (0.18, 0.30) | 382 | 0.61 | 0.31 (0.23, 0.38) |
| Iowa | 148 | 0.51 | 0.29 (0.18, 0.39) | 95 | 0.65 | 0.41 (0.28, 0.55) |
| P | 0.43 | 0.18 | ||||
| AJCC stage | ||||||
| Early (I–II) | 238 | 0.45 | 0.26 (0.18, 0.34) | 171 | 0.56 | 0.34 (0.23, 0.44) |
| Late (III–IV) | 391 | 0.53 | 0.17 (0.10, 0.24) | 292 | 0.65 | 0.21 (0.11, 0.30) |
| Other/unknown | 35 | 0.37 | 0.15 (−0.07, 0.37) | 14 | 0.71 | 0.53 (0.14, 0.91) |
| P | 0.25 | 0.09 | ||||
| Histologic type | ||||||
| Serous | 298 | 0.57 | 0.21 (0.13, 0.30) | 235 | 0.66 | 0.19 (0.08, 0.31) |
| Mucinous | 75 | 0.44 | 0.26 (0.12, 0.40) | 37 | 0.59 | 0.37 (0.13, 0.61) |
| Endometrioid | 97 | 0.46 | 0.26 (0.14, 0.39) | 82 | 0.55 | 0.34 (0.20, 0.49) |
| Clear cell | 62 | 0.24 | 0.00 (−0.11, 0.12) | 39 | 0.36 | 0.04 (−0.12, 0.20) |
| Other | 132 | 0.49 | 0.16 (0.05, 0.27) | 84 | 0.71 | 0.31 (0.13 0.48) |
| P | 0.01 | 0.04 | ||||
Key: MES, Mark E. Sherman; SEER, Surveillance, Epidemiology, and End Results; FIGO, International Federation of Gynecology and Obstetrics grading scheme; n, number; p0, observed agreement; κ, standard Kappa coefficient; P, two-sided P-value for χ2 test of heterogeneity across strata; AJCC, American Joint Committee on Cancer