Table 4.
Percent agreement and standard Kappa coefficients for MES versus SEER using SS three-tier grading schemes for: 4A) all 664 ovarian tumors and 4B) restricted to tumors with assigned grade (low, intermediate, or high) and also classified as invasive by the study pathologist
| 4A: SS, all SEER tumors | 4B: SS, restricted | |||||
|---|---|---|---|---|---|---|
| low/intermediate/high | low/intermediate/high | |||||
| n | p0 | κ (95% CI) | n | p0 | κ (95% CI) | |
| Overall | 664 | 0.43 | 0.20 (0.15, 0.24) | 447 | 0.57 | 0.27 (0.21, 0.34) |
| Registry | ||||||
| Hawaii | 516 | 0.42 | 0.18 (0.13, 0.24) | 356 | 0.56 | 0.25 (0.17, 0.32) |
| Iowa | 148 | 0.46 | 0.24 (0.14, 0.34) | 91 | 0.62 | 0.37 (0.23, 0.52) |
| P | 0.32 | 0.12 | ||||
| AJCC stage | ||||||
| Early (I–II) | 238 | 0.37 | 0.17 (0.09, 0.24) | 159 | 0.48 | 0.25 (0.15, 0.35) |
| Late (III–IV) | 391 | 0.48 | 0.15 (0.09, 0.22) | 274 | 0.62 | 0.19 (0.10, 0.28) |
| Other/unknown | 35 | 0.37 | 0.15 (−0.07, 0.36) | 14 | 0.64 | 0.39 (−0.04, 0.81) |
| P | 0.96 | 0.50 | ||||
| Histologic type | ||||||
| Serous | 298 | 0.53 | 0.20 (0.12, 0.28) | 224 | 0.63 | 0.18 (0.08, 0.29) |
| Mucinous | 75 | 0.39 | 0.19 (0.05, 0.32) | 34 | 0.56 | 0.29 (0.02, 0.56) |
| Endometrioid | 97 | 0.41 | 0.21 (0.09, 0.33) | 77 | 0.52 | 0.31 (0.16, 0.46) |
| Clear cell | 62 | 0.11 | −0.04 (−0.12, 0.04) | 37 | 0.16 | 0.00 (−0.08, 0.08) |
| Other | 132 | 0.41 | 0.11 (0.01, 0.20) | 75 | 0.65 | 0.26 (0.10, 0.42) |
| P | <0.001 | <0.001 | ||||
Key: MES, Mark E. Sherman; SEER, Surveillance, Epidemiology, and End Results; SS, Shimizu and Silverberg grading scheme; n, number; p0, observed agreement; κ, standard Kappa coefficient; P, two-sided P-value for χ2 test of heterogeneity across strata; AJCC, American Joint Committee on Cancer