Fig. 3.
MRIgFUS facilitates the entry of IgG and IgM into the brain. Using immunohistochemistry, high levels of IgG were detected in MRIgFUS-treated compared to untreated cortex of TgCRND8 (A) and non-Tg (B) mice. Similarly, IgM observed in MRIgFUS-treated cortical regions was greater than that detected in contralateral cortex of TgCRND8 (C) and non-Tg mice (D). Quantitative western blot analysis revealed that compared to untreated cortex, the cortex treated with MRIgFUS had greater levels of IgG in TgCRND8 (E) and non-Tg (F) mice; and of IgM in TgCRND8 (G) and non-Tg (H) mice. Scale bar: A–D= 500 μm. Data are presented as the mean ± SEM, *p<0.05.