Fig. 6.

Levels of Iba1 and GFAP protein expression in response to MRIgFUS in TgCRND8 and non-transgenic mice. Iba1 protein levels were significantly increased at 4 hours post-treatment in the MRIgFUS-treated cortex (FUS, grey column) relative to the left, untreated cortex (UT, white column) in TgCRND8 (A) and non-Tg (B) mice. At 4 days, Iba1 levels remained elevated in the MRIgFUS-treated cortex of transgenic (C) and non-Tg mice (D). E–F, At 15 days, no statistical difference was found between treated and untreated cortical levels of Iba1. GFAP protein levels were not different between MRIgFUS-treated and untreated cortex at 4 hours (G–H), but they were significantly increased in the MRIgFUS-targeted cortex at 4 days in TgCRND8 (I) and non-Tg (J) mice. At 15 days post-MRIgFUS treatment, TgCRND8 mice had a significant increase in GFAP levels in the MRIgFUS-treated cortex (K), whereas GFAP levels in the MRIgFUS-treated cortex of non-Tg mice were not statistically different from the untreated cortex (L). Mean ± SEM shown, *p<0.05, **p<0.01.