Table 2. Changes in mean measurements and in specific features in patients with Best vitelliform macular dystrophy.
| Mean measurements and specific features | Study entry | Last visit (41.14±18.5 months) | P(1) | P(2) | P(3) |
|---|---|---|---|---|---|
|
BCVA (LogMAR) |
0.34±0.34 |
0.32±0.33 |
0.2 |
|
- |
|
Overall lesion area (mm2) |
6.62±4.9 |
7.34±6.1 |
0.05 |
0.03 |
0.04 |
|
Hyperautofluorescent component of the lesion (mm2) |
4.10±3.7 |
4.16±3.7 |
0.3 |
0.06 |
0.05 |
|
Hypoautofluorescent component of the lesion (mm2) |
2.94±2.7 |
3.20±2.8 |
0.7 |
0.07 |
0.06 |
|
FAF fovea (n) |
Hypo=29 / Hyper=3 / Iso=10 |
Hypo=29 / Hyper=3
/ Iso=10 |
- |
0.7 |
0.7 |
|
EZ status fovea (n) |
Normal=15 / Disrupted=14/
Absent=13 |
Normal=13 / Disrupted=16 /Absent=13 |
- |
<0.001 |
<0.001 |
|
OCT reflectivity (n) |
Mixed=22 / Hyper=12 /
Hypo=3 |
Mixed=22 / Hyper=12 / Hypo=3 |
- |
0.2 |
0.4 |
|
Maximal OCT lesion thickness (μm) |
299.87±187.8 |
315.21±161.0 |
0.5 |
0.03 |
0.03 |
|
Maximal OCT lesion width (μm) |
2503.41±975.0 |
2546.07±1125.2 |
0.1 |
0.4 |
0.6 |
|
OCT neurosensory retinal thickness fovea (μm) |
89.25±28.5 |
90.85±40.9 |
0.9 |
0.03 |
0.02 |
| CMT (μm) | 341.08±178.5 | 351.17±156.7 | 0.8 | 0.1 | 0.2 |
BCVA: best-corrected visual acuity; CMT: central macular thickness; FAF: fundus autofluorescence; EZ: Ellipsoid Zone; LogMAR: logarithm of the minimal angle of resolution; n: number of eyes; OCT: optical coherence tomography; RPE: retinal pigment epithelium; P (1) statistical significance of change between baseline and last visit; P (2) statistical significance of correlation with BCVA at baseline; P (3) statistical significance of correlation with BCVA at last follow up visit.