Figure 2.

Pretreatment with anatabine trended toward a dose-dependent reduction of nicotine self-administration (mean ± S.E.M.). There was a nearly significant reduction of nicotine self-administration at the 0.2 mg/kg dose of anatabine (mean 5.54 ± 0.77, p = 0.08), compared to vehicle control (avg. 7.38 ± 0.83) while a statistically significant reduction of average infusions per session was observed at the 2.0 mg/kg dose (p < 0.005, mean 3.83 ± 0.58). (n = 12)