Table 1.

Table: A comprehensive analysis of the hemostasis and thrombosis phenotypes in mice with defects in signaling molecules upstream of PLCγ2. (↓ mild, ↓↓ moderate, ↓↓↓ severe platelet defect response)

Molecule	Approach	Ca²⁺ mobilization	Secretion	Aggregation	Thrombosis	Bleeding time	references
Fyn/Lyn	Fyn^−/−	↓	↓ alpha granules ↓ dense granules	↓ (only to low dose agonist)	normal thombus formation on collagen in vitro	normal	^126,127,128
	Lyn^−/−	↑ (delay)	↑ alpha granules ↑ dense granules	↑ (delay)	↓ thrombus formation on collagen in vitro ↓ thrombosis after laser injury in arterioles	normal
	Fyn^−/− Lyn^−/−		↓ dense granules	↓	↓ thrombus formation on collagen in vitro
Syk	Syk^−/−		↓↓↓ dense granules	↓↓↓	↓↓↓ thrombus formation on collagen in vitro	normal
Syk	inhibitor			↓↓↓	instable thrombi on collagen in vitro protective in several models of thrombosis, including photochemical injury to carotid artery, pulmonary thromboembolism, and HIT	normal	^{129,62,16,130,131, 132, 63}
LAT	Lat^−/−		↓↓ dense granules	↓ (only to low dose agonist)	↓ thrombus formation on collagen in vitro	normal	^{133,134,135,136, 16}
Gad	Gad^−/−		↓↓ dense granules	↓ (only to low dose agonist)	normal thrombus formation on collagen in vitro		^{134, 135}
Vav	Vav1^−/− Vav2^−/− Vav3^−/−			Vav2^−/−: no defect Vav3^−/−: no defect Vav1^−/−: ↓ Vav1^−/−/Vav2 ^−/−: ↓ Vav1^−/−/Vav3^−/−: ↓↓			^{52, 51, 50,137,16}
Vav	Vav1/2/3^−/−			↓↓↓	↓ thrombus formation on collagen in vitro delayed time to occlusion after FeCl₃ injury to the carotid artery		^{52, 51, 50,137,16}
Slp76	Slp76^−/−	↓↓↓	↓↓↓ alpha granules	↓↓↓ (overcome at high agonist concentrations)	↓↓↓ thrombus formation on collagen in vitro		^45,138
PLCγ2	PLCγ2^−/−	↓↓	↓↓↓ alpha granules ↓↓↓ dense granules	↓↓↓	↓↓↓ thrombus formation on collagen in vitro ↓↓↓ thrombosis in a superficial laser injury model	↑↑	^{66,139,64,140, 141, 65, 16, 142}
Rac1	Rac1^−/−	↓	↓↓↓ alpha granules ↓↓↓ dense granules	↓ (only to low dose agonist)	↓↓↓ thrombus formation on collagen in vitro ↓↓↓ arterial thrombosis (laser injury, cremaster) ↓↓↓ arterial thrombosis (carotid artery ligation)	↑	^{47, 48, 49}
Rac1	inhibitor	↓	↓↓↓ alpha granules ↓↓↓ dense granules	↓ (only to low dose agonist)			^{47, 48, 49}
STAT3	inhibitor			↓↓ (only to low dose agonist)	↓↓ thrombus formation on collagen in vitro		⁴⁶