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. 2014 Apr 7;111(16):5902–5907. doi: 10.1073/pnas.1320350111

Fig. 2.

Fig. 2.

Cardiac hypertrophy is exacerbated in Erbin−/− mice. (A) HW:BW ratios in Erbin−/− mice and their normal littermates (WT) at baseline (Con) and after treatment with isoproterenol (Iso) for 7 d. Results are expressed as mean ± SEM (n = 5–7). *P < 0.05. (B and C) Echocardiography of WT and Erbin−/− mice. Shortening fraction (B) and fold increase in diastolic interventricular septal thickness (IVSD) (*P = 0.01) (C) were measured at baseline (Con) and after treatment with isoproterenol (Iso) for 7 d. Results represent mean ± SEM (n = 5–7). *P < 0.05. (D) Cardiomyocyte diameter of WT and Erbin−/− mice at baseline and after isoproterenol administration for 7 d. Results represent mean ± SEM (n = 5–7). *P < 0.05. (E) H&E staining of hearts derived from WT and Erbin−/− mice after treatment with isoproterenol for 7 d. One representative slide is shown out of six. (Scale bars, 50 μM.) (Lower) Magnification (6×) of the boxed areas (Upper). Several of the fibroblasts are marked by arrows. (F) LW:BW ratios in Erbin−/− mice and their normal littermates (WT) at baseline (Con) and after treatment with isoproterenol (Iso) for 7 d. Results represent mean ± SEM (n = 7–10). *P < 0.05.