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Reduced cocaine self-administration in OX1R KO mice is restored by KOR blockade. Impairment of orexin signaling at OX1R by genetic deletion of this receptor reduces i.v. self-administration of cocaine (0.3 mg/kg per infusion). This deficit is partially rescued by pretreatment with norBNI (10 mg/kg, i.p.) (n = 7). *P < 0.05 between groups; ^^P < 0.01 within groups.
