JS divergence for Vβ, Jβ and Vα, Jα segment usage of out-of-frame clonotypes. Each column indicates the JS divergence divided by the mean entropy (for each pair) between an individual and five other individuals. Error bars indicate SD calculated using the bootstrap analysis. Red circles, individuals A1 or A2; blue circles, individuals C1 or C2; green circles, individuals D1 or D2.