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. 2014 Apr 7;111(16):5968–5973. doi: 10.1073/pnas.1318810111

Fig. 2.

Fig. 2.

SNPs associated with the euphoric response to d-amphetamine are enriched among SNPs associated with protection from schizophrenia. A shows a schematic representation of the enrichment analysis. There was a significant enrichment of SNPs that were nominally associated with schizophrenia from the PGC1 Schizophrenia sample among SNPs nominally associated with the euphoric response to d-amphetamine; the enrichment was significant with P value thresholds of (Center) P ≤ 0.01 or (Right) P ≤ 0.05. The black dots represent the observed number of overlapping SNPs. The histograms represent the null distribution of overlapping SNPs generated from 1,000 random permutations of the amphetamine data. B shows the same analysis as A, except that SNPs were only considered if they were (Upper) concordant in direction or (Lower) discordant in direction. These results indicate that the discordant SNPs are responsible for the enrichment observed in A. AMPH, d-amphetamine; SCZ, schizophrenia. *P < 0.05.