Table 2. Univariate and multivariate analyses of lymph node metastasis risk factors of EGC.

Clinicopathological features	Univariate analysis			Multivariate analysis
	RR (95% CI)	P		RR (95% CI)	P
Gender
Male vs. female	0.923 (0.312-2.728)	0.885
Age (year)
<60 vs. 360	0.915 (0.340-2.462)	0.860
Tumor location
Upper 1/3	1.000	0.955
Middle 1/3	0.855 (0.178-4.115)	0.845
Lower 1/3	1.107 (0.362-3.390)	0.858
Macroscopic type
I/II vs. III/Mixed	2.234 (0.826-6.041)	0.113
Size (cm)
<2.0 vs. 32.0	1.682 (0.600-4.716)	0.323
Histology
Adenocarcinoma vs. other types*	0.730 (0.229-2.325)	0.594
Differentiation
Differentiated vs. undifferentiated	2.010 (1.062-3.805)	0.032		2.031 (1.035-3.986)	0.039
Ulcer
Absent vs. present	1.279 (0.347-4.717)	0.712
Lymphovascular invasion
Absent vs. present	9.053 (3.015-27.183)	0.000		6.102 (1.846-20.170)	0.003
Depth of invasion
Mucosa vs. submucosa	6.808 (1.898-24.415)	0.003		4.237 (1.107-16.222)	0.035

EGC, early gastric cancer; RR, relative risk; *, signet-ring cell carcinoma, mucinous adenocarcinoma and et al.