Table 1.
MicroRNAs linked to HSCs.
| miRNA | Predicted target and confirmation level | Putative pathway in fibrosis | References | Expression during HSCs activation |
|---|---|---|---|---|
| miR-15b | Reporter gene assay (Bcl-2) | Apoptosis | [26] | ↓ |
| miR-16 | Reporter gene assay (Bcl-2) Target protein changes (CCND1) |
Apoptosis cell cycle and cell proliferation |
[26, 29] | ↓ |
| miR-126 | Reporter gene assay (VEGFA) | VEGF/PI3k/Akt/CCND1 pathway and VEGF-A/Ca2+ pathway | [42] | ↓ |
| miR-122 | Target mRNA changes (P4HA1) | Collagen production | [27] | ↓ |
| miR-150 | Target protein changes (cmyb) | Cell activation and proliferation | [23] | ↓ |
| miR-19b | Reporter gene assays (TGF-βRII) | TGF-β signaling | [37] | ↓ |
| miR-194 | Target protein changes (rac1) | Cell activation and proliferation | [32] | ↓ |
| miR-195 | Reporter gene assays (cyclin E1) | Cell proliferation | [35] | ↓ |
| miR-29 family | Reporter gene assays (different collagens, PDGF-C, VEGF-A, and IGF-I) |
ECM synthesis | [34, 40, 43] | ↓ |
| miR-335 | Target mRNA changes (tenascin-C) | Cell activation and migration |
[25] | ↓ |
| miR-146a | Reporter gene assays (smad4) | TGF-β signaling | [33] | ↓ |
| miR-34a | Reporter gene assay (ACSL1) | Lipids biosynthesis | [28] | ↑ |
| miR-27b, miR-27a | Reporter gene assay (RXR-a) | Lipid accumulation and cell proliferation |
[30] | ↑ |
| miR-199a/b | Reporter gene assay (Dyrk1) | ECM synthesis via calcineurin/NFAT signaling |
[28] | ↑ |
| miR-221/222 | Reporter gene assay (CDKN1B) | Cell activation | [24] | ↑ |
| miR-21 | Target protein changes (PTEN) | PTEN/Akt pathway | [31] | ↑ |
| miR-181b | Reporter gene assay (P27) | Cell proliferation | [36] | ↑ |