Table 2.
Summary of modeled somatic kinase mutations.
| Kinase | Mutations | Activation status |
|---|---|---|
| ABL | L248V, T315I/L/N | Activating |
| G321E, Y353H, L387M | Activating | |
|
| ||
| EGFR | L718/P | Activating |
| G719C/A/R/D/V/S | Activating | |
| G721D | Activating | |
| L747S/P/F | Activating | |
| V765M, V769L, T790M | Activating | |
| G796S, L833V, T854A | Activating | |
| D855 | Inactivating | |
| L858R, L861Q/R | Activating | |
|
| ||
| BRAF | G466E/V, D594E/V, G596R | Inactivating |
| L597V/S/Q/R/L | Activating | |
| A598V, T599I/A, V600E/K/R/M | Activating | |
|
| ||
| FGFR2 | I548V, N550K, E565G, E565A | Activating |
| N549H, N540K, K526E, | Activating | |
| K660E, R678G, K641R, G663E | Activating | |
| E636K, M640I, I642V, R759Q, E475K | Inactivating | |
| D530N, A648T, G701S | Inactivating | |
|
| ||
| FGFR3 | I538V, N540K, K650E | Activating |
| K508 | Inactivating | |
|
| ||
| FGFR4 | P712T, H713R, S772N, D127H | Activating |
| K503M | Inactivating | |
|
| ||
| MAP2K4 | Q142L, R134Q | Activating |
| R154W, P326L, S251N, N234I | Inactivating | |
|
| ||
| DAPK3 | T112M, D161N, P216S | Inactivating |
|
| ||
| HCK | D378G | Inactivating |
|
| ||
| LYN | D385G | Inactivating |
|
| ||
| LKB1 | D194V | Inactivating |
|
| ||
| FYN | G410R | Inactivating |
|
| ||
| EPHA3 | R728L, K761N, D678E, G766E, D806N | Inactivating |
|
| ||
| MAPK8 | G171S | Inactivating |
|
| ||
| CDK11 | G175S | Inactivating |
|
| ||
| MAST205 | G655A | Inactivating |
|
| ||
| TRKB | T695I, D751N | Inactivating |
|
| ||
| ERBB2 | I767M, D769H/Y, V773AV777L, | Activating |
| T798M, G804S, Y835F, V842I, | Activating | |
| T862A, L866R, L869Q, R896C | Activating | |
| K753M | Inactivating | |
|
| ||
| ERBB3 | V714M, Q809R, V855A, S846I, E298C | Activating |
|
| ||
| ERBB4 | V696I, A748S, E785K, R757Q, P829Q, T901M | No effect on kinase activity |
| K726R, D818N, D836Q | Inactivating | |